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“It could be a game changer for those who struggle with obesity, which affects over 40% of American adults.” For the Semaglutide Treatment Effect in People with Obesity (STEP) 1 trial, Kushner and colleagues analyzed data from 1,961 adults without diabetes with a BMI of at last 30 kg/m² or at least 27 kg/m² with a weight-related comorbid condition